**Prepare the Burger Patties**
In a mixing bowl, combine the ground beef, salt, pepper, Italian seasoning, garlic powder, onion powder, red pepper flakes (if using), Parmesan cheese, and Worcestershire sauce. Mix until just combined. Form into 4 evenly sized patties.
**Cook the Patties**
- **Grill Method**: Preheat the grill to medium-high heat. Cook the patties for 4-5 minutes per side, or until they reach your desired doneness.
- **Skillet Method**: Heat a skillet over medium-high heat and cook the patties for 4-5 minutes per side.
**Melt the Cheese**
During the last minute of cooking, place a slice of mozzarella cheese on each patty and cover with a lid to melt.
**Toast the Buns**
Spread butter on the cut sides of the burger buns. Toast them in a skillet or under a broiler until golden brown.
**Assemble the Pizza Burgers**
- Spread a spoonful of marinara sauce on the bottom bun.
- Place the cooked patty with melted mozzarella on top.
- Add a few slices of pepperoni (if using).
- Spoon more marinara sauce over the burger.
- Sprinkle with fresh basil or oregano for extra flavor.
- Place the top bun on and serve immediately.