Combine Ingredients: In a medium saucepan, mix together the ketchup, bourbon, apple cider vinegar, and brown sugar for a smooth base.
Add Seasonings: Stir in Worcestershire sauce, smoked paprika, garlic powder, and onion powder. Blend until well incorporated.
Simmer: Bring the mixture to a gentle boil over medium heat. Reduce the heat and let it simmer for about 15-20 minutes, stirring occasionally until thickened.
Taste and Season: Add salt and pepper as desired. Feel free to adjust sweetness or spiciness based on your preference.
Cool and Store: Remove from heat, let it cool, and transfer to a jar or airtight container. Your homemade Bourbon BBQ Sauce is ready to enjoy!